Subchondral Bone Plate Changes More Rapidly than Trabecular Bone in Osteoarthritis
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چکیده
منابع مشابه
Subchondral Bone Plate Changes More Rapidly than Trabecular Bone in Osteoarthritis
Osteoarthritis (OA) is the most common joint disorder, characterised by focal loss of cartilage and increased subchondral bone remodelling at early OA stages of the disease. We have investigated the temporal and the spatial relationship between bone remodelling in subchondral bone plate (Sbp) and trabecular bone (Tb) in Dunkin Hartley (DH, develop OA early) and the Bristol Strain 2 (BS2, contro...
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Introduction: Osteoarthritis (OA) is a disease of a whole joint. Yet most of the diagnostic methods are focused mainly on cartilage degeneration and erosion. However, there is increasing evidence that the subchondral bone significantly contributes to the pathogenesis of OA. It has even been suggested that first tissue-level changes in OA occur in the subchondral bone before any signs of degener...
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Osteoarthritis (OA) is characterised by progressive degenerative damage to articular cartilage, but ultimately the disease affects the whole joint, with important implications for the affected limb and the entire body (Martel-Pelletier and Pelletier, 2010; Edmonds, 2009). There has been an ongoing debate regarding the origins of OA, and specifically whether it initiates in the bone or the carti...
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OBJECTIVE To test the hypothesis that changes in subchondral bone are significantly different among three canine models of osteoarthritis (OA). DESIGN In 21 purpose-bred mongrel dogs, OA was induced in one knee joint via either anterior cruciate ligament transection (ACLt; n = 5), medial femoral condylar groove creation (GR; n = 6), or medial meniscal release (MR; n = 5). Five dogs that had s...
متن کامل0762 - Trabecular Bone Strain Changes Associated with Subchondral Bone Defects in the Tibial Plateau
Introduction: Subchondral bone defects in the proximal tibia are commonly encountered with tibial plateau fractures. Bone defects and grafting treatments affect knee mechanics but the effects are not well understood. Changes in subchondral strain affect cartilage stress which likely contributes to posttraumatic arthritis. Historically, investigators have had to use analytical models to study tr...
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2016
ISSN: 1422-0067
DOI: 10.3390/ijms17091496